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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4524 |
SBC-110736
SBC110736 |
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-110736 是一种蛋白转化酶枯草杆菌蛋白酶 9 型 (PCSK9) 抑制剂。 | |||
T2626 |
SBC-115076
SBC115076 |
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-115076 是前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型(PCSK9)抑制剂。其中PCSK9 是一种前蛋白转化酶,在 LDL 受体代谢中的重要物质。 | |||
TP1881L1 |
Pep 2-8 ammonium salt(1541011-97-5 free base)
|
Others | Others |
Pep 2-8 ammonium salt(1541011-97-5 free base) 是 Proprotein 转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 抑制剂。 PCSK9 与 LDL 受体结合的强效抑制剂 (IC50 = 0.8 μM)。恢复用 PCSK9 处理的 HepG2 细胞中的 LDL 摄取。 | |||
T9920 |
Evolocumab
|
Others | Others |
Evolocumab 是人源化单克隆抗体PCSK9的抑制剂。它与循环的 PCSK9 蛋白结合,使得PCSK9与 LDLR 结合受到抑制。它可用研究于高胆固醇血症以及动脉粥样硬化性心血管疾病的研究。 | |||
T16491 |
PF-06446846 hydrochloride
|
Others | Others |
PF-06446846 hydrochloride 是一种口服活性高、高选择性PCSK9(前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型)翻译抑制剂。它通过在密码子34附近诱导核糖体暂停来抑制PCSK9。 | |||
T72025 |
PCSK9-IN-10
|
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
PCSK9-IN-10 是一种有效的,具有口服活性的PCSK9抑制剂,IC50值为 6.4 µM。PCSK9-IN-10 增加LDLR 蛋白的表达并降低 PCSK9 的表达。PCSK9-IN-10 可减缓动脉粥样硬化进展。PCSK9-IN-10 具有研究高脂血症的潜力。 | |||
T70069 |
MDK6465
|
||
MDK6465, also known as PCSK9-IN-8b, is a novel liver-targeted inhibitor of ribosomal synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9). MDK6465 has CAS#1900686-46-5. the last 4 digits are used in its name. | |||
TP1881 |
Pep2-8
Pep 2-8 |
||
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9. | |||
T72221 |
PF-06815345 hydrochloride
|
||
PF-06815345 hydrochloride 是一款口服有效的PCSK9抑制剂,其IC50值为13.4 μM。在小鼠体内,能显著降低PCSK9水平。 | |||
T60541 |
PCSK9 modulator-2
|
||
PCSK9 modulator-2 (Compound 1) 是一种有效的PCSK9调节剂(EC50 = 202 nM), 具有用于高脂血症的研究潜力。PCSK9 是降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T75545 | PCSK9-IN-9 | ||
PCSK9-IN-9 是一种天然来源的异香豆素。PCSK9-IN-9 可抑制原蛋白转化酶枯草菌素 kexin 型 9 (PCSK9)、IDOL 和 SREBP2的 mRNA 表达水平。PCSK9-IN-9 抑制 PCSK9的 IC50为 11.9 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00408 |
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)
FH3,proprotein convertase subtilisin |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is AAV67948.1. | |||
TMPY-04966 |
PCSK9 Protein, Human, Recombinant (D374Y, His)
LDLCQ1,NARC-1,PC9,NARC1,HCHOLA3,proprotein... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1. | |||
TMPY-05131 |
PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated
NARC-1,PC9,LDLCQ1,NARC1,FH3,proprotein |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 74.3 kDa and the accession number is Q8NBP7-1. | |||
TMPJ-00443 |
PCSK9 Protein, Macaca nemestrina, Recombinant (His)
Proprotein Convertase Subtilisin/... |
Macaca nemestrina | HEK293 Cells |
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development. | |||
TMPY-00995 |
PCSK9 Protein, Rhesus, Recombinant (His)
proprotein convertase subtilisin/... |
Rhesus | HEK293 Cells |
PCSK9 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.7 kDa and the accession number is A8T666. | |||
TMPY-01565 |
PCSK9 Protein, Rat, Recombinant (His)
proprotein convertase subtilisin/... |
Rat | HEK293 Cells |
PCSK9 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A6JYM6. | |||
TMPJ-00368 |
PCSK9 Protein, Human, Recombinant (Avi), Biotinylated
Subtilisin/Kexin-Like Protease PC9 |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7. | |||
TMPJ-00369 |
PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated
Subtilisin/Kexin-Like Protease PC9 |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-8xHis-HA-Avi tag. The predicted molecular weight is 18 and 58-70 and 90-150 KDa and the accession number is Q8NBP7. | |||
TMPY-05270 |
PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated
FH3,NARC-1,PC9,LDLCQ1,proprotein conve... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1. | |||
TMPY-05199 |
PCSK9 Protein, Human, Recombinant (D374Y, mFc)
PC9,proprotein convertase sub... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1. | |||
TMPY-05218 |
PCSK9 Protein, Human, Recombinant (mFc)
HCHOLA3,PC9,proprotein convertase... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.4 kDa and the accession number is Q8NBP7-1. | |||
TMPY-05114 |
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated
LDLCQ1,NARC-1,PC9,FH3,NARC1,HCHOLA3,proprotein<... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q8NBP7-1. | |||
TMPY-05217 |
PCSK9 Protein, Mouse, Recombinant (mFc)
HCHOLA3,Narc1,AI415265,AI747682,FH3,proprotein ... |
Mouse | HEK293 Cells |
PCSK9 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.6 kDa and the accession number is Q80W65. | |||
TMPY-01245 |
PCSK9 Protein, Mouse, Recombinant (His)
proprotein convertase subtilisin/... |
Mouse | HEK293 Cells |
PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65. | |||
TMPK-00483 |
PCSK9 Protein, Cynomolgus, Recombinant (His)
PCSK9 |
Cynomolgus | HEK293 Cells |
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated. | |||
TMPJ-00865 |
VEGF121 Protein, Human, Recombinant (His)
VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu... |
Human | HEK293 Cells |
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel... | |||
TMPY-03698 |
VEGF121b Protein, Human, Recombinant
MVCD1,VEGF,VPF,vascular endothelial growth factor A |
Human | HEK293 Cells |
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9. | |||
TMPH-00005 |
YAP1 Protein, Human, Recombinant (Isoform 9, His)
YAP1-2delta |
Human | P. pastoris (Yeast) |
YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9. | |||
TMPK-00825 |
VEGF121 Protein, Human, Recombinant (His & Avi)
VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609 |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9. | |||
TMPK-00826 |
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MV... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9. | |||
TMPY-05268 |
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated
NRCAML,neurofascin,NF |
Human | HEK293 Cells |
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9. |